Practical Considerations in Managing Diabetes in People with Chronic Kidney Disease

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Implementation of kidney protective medications in patients with diabetes is challenging. This module highlights the complexities of managing diabetes, including medication access and addressing disparities in care to provide practical guidance for the pharmacist to optimize medication management. This module supplements the previous medication focused modules that more comprehensively review the contemporary management of diabetes.

By the end of this module, learners will be able to:

Medication Therapy Problems in Chronic Kidney Disease

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Patients with chronic kidney disease are often prescribed numerous medications to treat comorbidities, slow the progression of their kidney disease, and to minimize morbidity and mortality. These complex medication regimens  lead to an increased potential for medication therapy problems. This module discusses common medication therapy problems associated with chronic kidney disease, medication reconciliation for this population, and the contributions that pharmacists can provide in medication therapy management.

By the end of this module, learners will be able to:

Hyperkalemia Prevention and Management in Chronic Kidney Disease

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Hyperkalemia is a significant risk of medications  that slow progression of chronic kidney disease. Oftentimes these medications or their optimal doses are avoided as a means to mitigate the risk of hyperkalemia, withholding the full potential benefit for our patients. Complicating this problem is the reality that evidence-based guidelines for managing hyperkalemia in patients with chronic kidney disease are sparse.

Value-Based Care Models and Pharmacist Reimbursement

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Value-based care has the potential to revolutionize the way pharmacists practice. The success of value-based programs are contingent upon patient outcomes, which are often influenced by the medication therapy problems. Thus, pharmacists are well positioned to be key members of value-based care teams to address complex medication therapy problems in patients with CKD. Value-based kidney care is in its infancy, so it is vital for the pharmacy workforce to be prepared and integrate into these programs.

By the end of this module, learners will be able to:

CKD Treatment: Addressing Kidney and Cardiometabolic Outcomes Part 5: Chronic Heart Failure Management

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The management of chronic heart failure in the setting of chronic kidney disease is an important topic, particularly for pharmacists, because the cornerstone for the treatment of heart failure is pharmacotherapy. Heart failure also remains the leading discharge diagnosis among patients greater than 65, and anywhere from 40 to 45% of individuals who have chronic heart failure also have some form of chronic kidney disease. In this module, we will cover the importance of guideline-directed medical therapy (GDMT), pharmacologic diuresis, and altering GDTM for those with CKD.

CKD Treatment: Addressing Kidney and Cardiometabolic Outcomes Part 4: Mineralocorticoid Receptor Antagonists

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A new non-steroidal mineralocorticoid receptor antagonist (MRA), finerenone, is FDA-approved for kidney and heart protection in patients with type 2 diabetes. In this module, we will be introducing the different MRAs that are commercially available and discussing the evidence to support their use in patients with kidney disease. This will include a focus on criteria for use of finerenone in our patients with type 2 diabetes, and the patient-specific considerations of when to use this medication.

CKD Treatment: Addressing Kidney and Cardiometabolic Outcomes Part 3: GLP1 Receptor Agonists

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The cardiovascular benefits of GLP1 RAs have been well characterized in several large cardiovascular outcome trials. The benefits of secondary kidney outcomes in those with diabetes have been observed in these trials. In this module, we will review current evidence supporting the benefits of GLP-1 RAs in the patients with kidney disease. We will also review current clinical guidelines and recommendations for their use and discuss medication and patient-specific efficacy and safety considerations when using them in people with type 2 diabetes and chronic kidney disease.

CKD Treatment: Addressing Kidney and Cardiometabolic Outcomes Part 2: SGLT2 inhibitors

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SGLT2 inhibitors are an addition to our pharmacotherapy toolkit that have cardio- and kidney-protective benefits for individuals with kidney disease. New information from clinical trials has prompted guideline updates from leading diabetes and nephrology organizations. In this module, we will review the supporting evidence and guidelines in addition to discussing clinical considerations for the optimal use of SGLT inhibitors in improving cardiometabolic and kidney outcomes.

CKD Treatment: Addressing Kidney and Cardiometabolic Outcomes Part 1: ACEIs/ARBs

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ACE inhibitors and ARBs have benefits beyond blood pressure control in people with kidney disease. These include slowing kidney disease progression, reducing albuminuria, and reducing cardiovascular risk. But data shows only a fraction of patients who are eligible for an ACEi or an ARB receive one. This module focuses on the evidence behind the role of ACEis and ARBs in patients living with kidney disease, and will also discuss how to safely initiate and monitor ACEis and ARBs in patients with kidney disease.

Practical Considerations in anti-hypertensive and diuretic use in CKD

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While hypertension is the second leading cause of CKD in the US, we also know that CKD can cause hypertension. Controlling blood pressure becomes more difficult as kidney disease progresses. In this module, we will cover pharmacologic and nonpharmacologic approaches to help individuals with late stage chronic kidney disease control their blood pressure.